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Literature summary extracted from

  • Kar, P.; Samanta, K.; Shaikh, S.; Chowdhury, A.; Chakraborti, T.; Chakraborti, S.
    Mitochondrial calpain system: an overview (2010), Arch. Biochem. Biophys., 495, 1-7.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpastatin mitochondrial mu-calpain is tightly regulated by its endogenous inhibitor calpastatin Rattus norvegicus
3.4.22.53 calpastatin endogenous inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.52 cytosol neuronal cytosol Rattus norvegicus 5829
-
3.4.22.52 mitochondrion mu-calpain, including both the large and small subunits is present in the mitochondrial intermembrane space Rattus norvegicus 5739
-
3.4.22.53 cytosol
-
 Rattus norvegicus 5829
-
3.4.22.53 mitochondrion m-calpain is present in the intermembrane space of the mitochondria Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ the enzyme is Ca2+-dependent Rattus norvegicus
3.4.22.53 Ca2+ dependent on Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.53 30000
-
 1 * 80000 + 1 * 30000 Rattus norvegicus
3.4.22.53 80000
-
 1 * 80000 + 1 * 30000 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.52 mature apoptosis-inducing factor (62 kDa) + H2O Rattus norvegicus cleaved by the mitochondrial mu-calpain near its N-terminus cleaved apoptosis-inducing factor (57 kDa) + ?
-
 ?
3.4.22.52 mitochondrial major Ca2+ extruding pathway Na+/Ca2+ exchanger + H2O Rattus norvegicus cleaved by the mitochondrial mu-calpain ?
-
 ?
3.4.22.53 additional information Rattus norvegicus ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Rattus norvegicus
-
-
-
3.4.22.53 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 liver
-
 Rattus norvegicus
-
3.4.22.52 neuron
-
 Rattus norvegicus
-
3.4.22.52 smooth muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 mature apoptosis-inducing factor (62 kDa) + H2O cleaved by the mitochondrial mu-calpain near its N-terminus Rattus norvegicus cleaved apoptosis-inducing factor (57 kDa) + ?
-
 ?
3.4.22.52 mitochondrial major Ca2+ extruding pathway Na+/Ca2+ exchanger + H2O cleaved by the mitochondrial mu-calpain Rattus norvegicus ?
-
 ?
3.4.22.52 additional information mitochondrial mu-calpain associates with ERp57, whereas, cytosolic mu-calpain does not associate with ERp57 Rattus norvegicus ?
-
 ?
3.4.22.53 additional information ERp75 plays important role in the refolding of mitochondrial m-calpain large subunit, cytosolic m-calpain does not associate with ERp57 Rattus norvegicus ?
-
 ?
3.4.22.53 voltage dependent anion channel + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.53 heterodimer 1 * 80000 + 1 * 30000 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain 1
-
 Rattus norvegicus
3.4.22.52 mu-calpain
-
 Rattus norvegicus
3.4.22.53 calpain 2
-
 Rattus norvegicus
3.4.22.53 m-calpain
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.22.52 Rattus norvegicus mu-calpain is activated in neurons after ischemia up

General Information

EC Number General Information Comment Organism
3.4.22.52 physiological function mitochondrial mu-calpain is an initiator of the apoptosis-inducing factor-induced cell death signaling pathway. Mitochondrial calpain plays important roles both in caspase-dependent and -independent pathways in cell death phenomena. Mu-calpain can act as a direct activator of apoptosis-inducing factor release in neuronal cultures challenged with oxygen-glucose deprivation Rattus norvegicus
3.4.22.53 physiological function mitochondrial m-calpain is associated with ERp75 and plays an important role in releasing of truncated apoptosis-inducing factor from mitochondria Rattus norvegicus